Drugs list > D > Dacarbazine


They say cancer still does not have a one-medicine-for-all type of cure. But, some aspects of it are already being treated with the drug called Dacarbazine. It’s an alkylating agent that is usually given to the patient through an intravenous infusion or by the way of an injection. 

Usually branded under the names DTIC-Dome, DTIC, DIC and Imidazole Carboxamide, Dacarbazine is used by patients who have soft tissue sarcomas, metastatic malignant melanoma, rhabdomyosarcoma, fibrosarcomas, neuroblastoma, carcinoma of the thyroid and islet cell carcinoma.

The drug can be administered to the patient through the cannula at the back of the hand - with an IV infusion. Another way is through a vein close to the collarbone which can be done with a thin plastic tube inserted into the vein. A vein of the PICC line may also serve as the drug’s entrance into the body. Whichever way, the administration of the drug may take from 30 minutes to 2 hours.

A patient’s treatment cycle and Chemotherapy depend on the kind of cancer that the person has. Dacarbazine may also be taken with other chemotherapy medications.

The exact amount of Dacarbazine that a patient has to use will rely on the overall health status of the patient, and the specific kind of cancer that is up for treatment.

It is necessary for patients on Dacarbazine to know that reaction to the drug is relatively subjective. One patient’s response may differ from another patient’s. Some may go through very little side effects, while others may experience a lot.

Feeling nauseated and vomiting may be evident in a patient immediately after taking the drug. Some may even feel that way for a couple of days. At this point, doctors normally recommend anti-emetic drugs so that the severity of the side effects would be lessened.

Another unpleasant side effect that manifests a week after the administration is the reduction in the bone marrow’s capacity to produce white blood cells. That opens up the body for easy infection. However, the number of white blood cells would increase again after a few weeks.

Blood clotting may also become a problem for patients using Dacarbazine. That’s because the number of platelets in the blood would be reduced, and the patient would experience unexplained bleeding, nosebleeds, bruises, blood spots and bleeding gums.

Anemia may set in, too. The number of red blood cells may be lowered and feeling exhausted and breathless may crop up.

Hair loss and appetite loss may develop, as well, with Dacarbazine use. Aside from all the effects mentioned above, diarrhea, pain on the area where the needle has pierced the skin, ulcers, flu-like symptoms and sunlight sensitivity may also take place.

If the aforementioned effects worsen or persist, in any way, a trip to the doctor is called for.

Patients who are taking prescription or OTC drugs, along with herbal supplements and other types of medications should inform their doctors about it. Aspirin use while on Dacarbazine medication is also highly-discouraged.

Immunizing oneself with shots is also another big no-no during Dacarbazine ingestion. It is completely unsafe.

Patients who are looking at starting a family need to understand, too, that Dacarbazine may affect a person’s fertility. Breastfeeding mothers can’t use the drug, too, because i may harm the child.

  • The chemical IUPAc name of Dacarbazine is 5-dimethylaminoazo-3H-imidazole-4-carboxamide
  • Molecular weight is 183.183 g/mol
  • Dacarbazine is available in 100 mg and 200 mg tablets
  • Dacarbazine’s molecular formula is C6H10N6O

Brand names: Biocarbazine R, Dtic-Dome, DTIC-Dome, , Dacarbazino, Dacarbazinum, Deticene, Imidazole Carboxamide

Related Medications: Adriamycin, Cytoxan, Trexall, Temodar, Intron A, Proleukin, DTIC-Dome, VepeSid, Leukeran, Oncovin, Velban, Blenoxane, Matulane, Toposar, Gliadel, Etopophos, Neosar, Cytoxan Lyophilized

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